Pharmacodynamic And Pharmacokinetic Interaction Of Didymocarpus Pedicellata With Gliclazide In Normal And Diabetic Rats
نویسندگان
چکیده
This study evaluated possible interaction between Ayurvedic anti-urolithiac agent hydroalcoholic extract of Didymocarpus pedicellata (HADP) leaves and gliclazide. Dose optimization performed by measuring serum glucose levels after 200 400 mg/kg HADP administration to normal rats. Pharmacokinetic in rats gliclazide alone combination with (400 mg/kg). Diabetes was induced streptozotocin (55 mg/kg) animals were treated gliclazide, for 28 days. dynamic assessed single (day 1) repeated dose 28) co-administration determination respectively. Gliclazide showed biphasic concentration time data reduction maximum at 2 8h post administration. proportionate hypoglycemic effect rats, hence used further studies. There significantly higher decrease percentage group as compared only normal, diabetic Reduction single. a non-significant increase pharmacokinetic parameters Repeated caused significant all On day biochemical are estimated evaluate on oral days animals. The results shown improvement dyslipidemia, triglyceride liver functional such SGOT, SGPT, ALP, total protein the vehicle control group. Combination pharmacodynamic Hence precautions has be observed dosage adjustments might required clinical setting avoid sever hypoglycemia.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2023
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2023.14.s02.195